Tadalafil and Sildenafil are phosphodiesterase-5 (PDE5) inhibitors used for treating impotence (erectile dysfunction, or ED).
Common side effects of Tadalafil and Sildenafil that are similar include flushing (redness or warmth of the face, neck, or chest), headaches, stomach pain or upset, flu-like symptoms (such as stuffy nose, sneezing, or sore throat), memory problems, muscle or back pain, blurred vision and changes in color vision (such as an inability to differentiate between the colors green and blue), dizziness, diarrhea, nausea, low blood pressure, abnormal ejaculation, and prolonged erections (priapism), loss of hearing, and ringing in the ears.
One difference between the drugs is how long they stay in your system. Tadalafil provides penile hardness (the ability to obtain an erection) over a longer period than Sildenafil because it lasts up to 18 hours, while Sildenafil only lasts for about 4 to 6.
Tadalafil and Sildenafil are oral drugs that are used for treating impotence (the inability to attain or maintain a penile erection) and benign prostatic hyperplasia (BPH). They are in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors that also includes vardenafil (Levitra, Staxyn ODT), and avanafil (Stendra). Penile erection is caused by the engorgement of the penis with blood. Under normal conditions, sexual stimulation leads to the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase, which causes the production of cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for the erection by affecting the amount of blood that the blood vessels deliver and remove from the penis. Tadalafil and Sildenafil inhibit an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP. Thus, Tadalafil and Sildenafil prevent the destruction of cGMP and allows cGMP to accumulate and persist longer. The longer cGMP persists, the more prolonged the engorgement of the penis.
Please be sure to read our FAQs for answers to frequently asked questions. If you still have additional questions or would like to get in touch with us simply submit a support ticket using the form below.
How can Smash help if you suffer from erectile dysfunction (E.D.)?
At Smash, we've invested in the capabilities of telemedicine by making E.D. treatment quick and easy. With Smash, most patients complete the initial doctor visit questionnaire in minutes. Shortly after, one of our U.S. Licensed physicians will review your answers within a few hours.
Your Doctor will need to know about your health, your medications, lifestyle decisions, prior surgeries, and E.D. Along with a recent blood pressure reading (within last 6 months), all this information will help your doctor curate your personal treatment. They will also need a personal ID so they know who they will be helping. Then, the doctor will review the information in private and determine if you are a suitable candidate for E.D. treatment through telemedicine (majority of men are) and will come up with a personalized treatment plan just for you.
At this point, we'll ship your treatment discreetly and fast!
What is E.D.?
What Causes E.D.?
Why is it important to seek help for E.D.?
Is it safe to use the E.D. service?
Why do you need to know my blood pressure?
I have the tools, how do I measure my own blood pressure at home?
To begin blood pressure measurement, use a properly sized blood pressure cuff. The length of the cuff's bladder should be at least equal to 80% of the circumference of the upper arm. Wrap the cuff around the upper arm with the cuff's lower edge one inch above the antecubital fossa. Lightly press the stethoscope's bell over the brachial artery just below the cuff's edge. Then, rapidly inflate the cuff to 180mmHg. Release air from the cuff at a moderate rate (3mm/sec). Listen with the stethoscope and simultaneously observe the sphygmomanometer. The first knocking sound (Korotkoff) is the subject's systolic pressure. When the knocking sound disappears, that is the diastolic pressure (such as 120/80). Record the pressure in both arms and note the difference; also record the subject's position (supine), which arm was used, and the cuff size (small, standard or large adult cuff). A BLOOD PRESSURE OF 180/120mmHg OR MORE REQUIRES IMMEDIATE ATTENTION!
For the purpose of accuracy, take 2 readings in both arms, and provide us the highest number recorded.
Who can use the E.D. service?
What medications do you prescribe?
Are the medications you prescribe effective?
Why can't I take nitrates or nitroglycerin with Sildenafil?
How is Smash different from other E.D. services?
What is the return & refund policy?
Is my information private?
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